a Record control number WOS:000330462400001

a ISSN 1076-1608

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WE 544

b Item number .P85 2013

a Personal name Akdogan, Ali.

h Medium Electronic Document

a Title Pulmonary Hypertension in Systemic Lupus Erythematosus Pulmonary Thromboembolism Is the Leading Cause

c Statement of responsibility, etc Ali Akdogan, Levent Kilic, Ismail Dogan, Sercan Okutucu, Elif Er, Baris Kaya, Lutfi Coplu, Meral Calguneri, Lale Tokgozoglu, Ihsan Ertenli.

a Place of publication, distribution, etc Philadelphia

b Name of publisher, distributor, etc Lippincott Williams & Wilkins,

c Date of publication, distribution, etc 2013.

a Summary, etc Background: Pulmonary hypertension (PH) is a life-threatening complication of systemic lupus erythematosus (SLE). Pulmonary hypertension in SLE has a variety of causes. Diagnosing early and defining the cause of PH accurately can provide better clinical outcome in SLE. We investigated the causes and characteristics of PH in patients with SLEMethods: One hundred twenty-one patients with SLE who had a visit in a 6-month period were assessed retrospectively. Patients who ever had a systolic pulmonary arterial pressure of 40 mm Hg or greater by Doppler echocardiography were considered to have PH.Results: Among 122 patients, 65 had echocardiography for some reason, and 10 (8.2%) were diagnosed as having PH by echocardiographic examination. This number reduced to 9 (7.4%) when we excluded the patient with normal pulmonary artery pressure at right heart catheterization. Causes of PH were as follows: thromboembolic events in 4 patients (44.4%) (2 of them had chronic thromboembolic PH), left-sided heart disease in 2 patients (22.2%), pulmonary arterial hypertension in 1 patient (11.1%), high cardiac output state in 1 patient (11.1%), and transient elevation of systolic pulmonary artery pressure in 1 patient (11.1%) who had a history of venous thromboembolism. Venous thromboembolic disease was significantly higher in patients with SLE with PH in comparison to patients with SLE without PH (7 patients [6.3%] vs 5 patients [50.0%]; P = 0.001). All patients improved clinically during their short-term follow-up.Conclusions: Patients with SLE are at increased risk for PH. This study highlights the complexity of the differential diagnosis of PH in patients with SLE once again and emphasizes the importance of pulmonary thromboembolism as a cause of PH. One should investigate patients with SLE with unexplained symptoms and/or signs related to PH for possible treatable causes.

a Topical term or geographic name as entry element Rheumatology.

a Topical term or geographic name as entry element Pulmonary hypertension

a Topical term or geographic name as entry element Systemic lupus erythematosus

a Topical term or geographic name as entry element Pulmonary thromboembolism

a Topical term or geographic name as entry element Connective-tissue-disease

a Topical term or geographic name as entry element Arterial-hypertension

a Topical term or geographic name as entry element Risk Factors.

a Topical term or geographic name as entry element Antiphospholipid antibodies

a Topical term or geographic name as entry element Sclerosis

a Topical term or geographic name as entry element Echocardiography

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information DEC 2013, Vol.19 Issue 8, p421-425

t Title Jcr-Journal Of Clinical Rheumatology

x International Standard Serial Number 10761608

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1097/RHU.0000000000000037